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. Author manuscript; available in PMC: 2021 Jan 30.
Published in final edited form as: Epilepsy Behav. 2017 Dec 22;78:124–133. doi: 10.1016/j.yebeh.2017.10.025

Figure 3: Blunted corticosterone levels in chronically epileptic Gabrd/Crh mice.

Figure 3:

a, Average circulating corticosterone levels in Gabrd/Crh mice and Cre−/− littermates at baseline and in chronically epileptic mice 60 days following pilocarpine-induced status epilepticus. The blunted corticosterone levels in chronically epileptic Gabrd/Crh mice are increased with exogenous corticosterone treatment (21-day slow-release corticosterone pellet). n = 9 – 19 mice per experimental group; * denotes p<0.05 using a one-way ANOVA. b, Representative images of c-fos expression in the PVN of Gabrd/Crh mice and Cre−/− littermates 60 days following pilocarpine-induced status epilepticus. c, The average number of c-fos-positive neurons in the PVN of Gabrd/Crh mice and Cre−/− littermates 60 days following pilocarpine-induced status epilepticus or in vehicle-treated controls. n = 6 sections/mouse, 3 mice per experimental group. * denotes p<0.05 using a two-way ANOVA.