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LBH reduced inflammation through inhibiting NLRP3 inflammasome activation in LPS-induced A549 cells. (a) MCC950 reversed the promoting effects of sh-LBH on the expression of IL-1β, IL-6, and IL-18 in LPS-induced A549 cells. ∗∗∗P < 0.001 vs. NC, ###P < 0.001 vs. sh-LBH. (b) MCC950 eliminated the facilitation effects on the NLRP3 and ASC protein expression in LPS-induced A549 cells caused by sh-LBH. ∗∗∗P < 0.001 vs. NC, ###P < 0.001 vs. sh-LBH.
