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. 2021 Jan 26;16:147–158. doi: 10.2147/COPD.S272711

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© 2021 Zhang et al.

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Rcn3 expression in lung tissues from the elastase-induced mouse model of emphysema. (A) Lungs after saline or PPE instillation at 0.2 U, 0.3 U and 0.4 U/per mouse were compared in H&E-stained tissue sections. Bar size: 100 μm; (B) The MLI analysis of lung sections after saline or PPE instillation (40.58 ± 0.53 μm, 56.10 ± 2.45 μm, 98.23 ± 3.21 μm and 71.22 ± 2.84 μm, respectively, n = 5 per group); (C) The PPE instillation induced the protein expressions of Rcn3, GRP78, Cleaved caspase-3, and the ratios to β-Tubulin expression are represented by graphs, n = 5 per group; (D) Qualitative PCR analysis of the mRNA expressions of Rcn3, GRP78, Collagen I (Col (I) and MMP-9 in the lungs at 4 weeks after PPE (0.3 U/per mouse) or saline treatment, n = 5 per group. Data presented as mean ± SEM; *p<0.05, **p<0.01, ***p<0.001, versus the Saline group, ^###p<0.001, versus the 0.3 U PPE group.