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. 2021 Jan 26;13:743–755. doi: 10.2147/CMAR.S272851

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© 2021 Fan et al.

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Circ_0031242 was overexpressed and associated with DDP resistance in HCC. The expression of circ_0031242 by qRT-PCR in 30 healthy hepatic tissues, HCC tissues from 30 primary patients (DDP-sensitive) and 30 recurrent patients after treatment with DDP-based chemotherapy (DDP-resistant) (A), THLE-2, Huh7, SNU-387, Huh7-R and SNU-387-R cells (B). (C) The IC₅₀ value of DDP by CCK-8 assay in Huh7, SNU-387, Huh7-R and SNU-387-R cells. *P < 0.05 by a two-tailed Student’s t-test or ANOVA followed by Tukey-Kramer post hoc test.