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. 2021 Jan 26;13:743–755. doi: 10.2147/CMAR.S272851

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© 2021 Fan et al.

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Circ_0031242 knockdown declined DDP resistance, cell viability, migration, invasion and accelerated apoptosis in Huh7-R and SNU-387-R cells. Huh7-R and SNU-387-R cells were transfected with si-NC or si-circ_0031242. (A) Circ_0031242 expression by qRT-PCR in transfected cells. (B) The IC₅₀ value of DDP in transfected cells by CCK-8 assay. (C) Cell viability by CCK-8 assay. (D and E) Cell migration and invasion by transwell assay. (F) Cell apoptosis by flow cytometry. (G) The levels of MRP1 and P-gp in transfected cells by Western blot. *P < 0.05 by a two-tailed Student’s t-test.