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. 2021 Jan 26;13:743–755. doi: 10.2147/CMAR.S272851

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© 2021 Fan et al.

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The regulatory impact of circ_0031242 silencing on DDP-resistant HCC cell behaviors was abated by miR-924 down-regulation. Huh7-R and SNU-387-R cells were transfected with si-NC, si-circ_0031242, si-circ_0031242+inhibitor NC or si-circ_0031242+miR-924 inhibitor, followed by the measurement of IC₅₀ value of DDP by CCK-8 assay (A), cell viability by CCK-8 assay (B), cell migration and invasion by transwell assay (C and D), cell apoptosis by flow cytometry (E), MRP1 and P-gp levels by Western blot (F). *P < 0.05 by ANOVA followed by Tukey-Kramer post hoc test.