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. 2021 Jan 26;13:743–755. doi: 10.2147/CMAR.S272851

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© 2021 Fan et al.

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The schematic model of the circ_0031242/miR-924/POU3F2 axis on DDP-resistant HCC cell progression and drug resistance. In DDP-resistant HCC tissues and cells, circ_0031242 was up-regulated, resulting in decreased miR-924. Then, the reduced miR-924 level elevated POU3F2 expression. Finally, the increased expression of POU3F2 enhanced DDP resistance, promoted cell viability, migration, invasion, as well as repressed apoptosis in DDP-resistant HCC cells, thereby leading to DDP-resistant HCC progression.