Table 1.

Demographic and cognitive profile of 122 PSEN1 E280A patients according to age of onset quartiles

Group	Patients	Gender (F)	ApoE2	ApoE3	ApoE4
Total	122	60.7%	3.3%	63.1%	23.8%
Q1: Early	33	72.7%	–	66.7%	24.2%
Q2–Q3: Average	61	57.4%	3.3%	63.9%	23.0%
Q4:Late	28	53.6%	7.1%	57.1%	25.0%
X Squared p value		0.237	0.31	0.886	0.982
			0.622

Age of onset	p value vs
	Mean	SD	Early	Average	Late
Early	44.21	1.95	–	0.000	0.000
Average	49.18	1.64	0.000	–	0.000
Late	56.96	3.79	0.000	0.000	–
Total	49.62	5.11	0.000
Schooling
Early	6.76	3.99	–	0.400	0.018
Average	5.49	3.88	0.400	–	0.261
Late	3.96	3.74	0.018	0.261	–
Total	5.48	3.97		0.022
MMSE
Early	19.06	5.48	–	0.384	0.26
Average	17.23	5.57	0.384	–	1.000
Late	16.61	5.50	0.260	1.000	–
Total	17.58	5.56		0.180
Memory
Early	− 0.47	0.45	–	0.094	0.097
Average	− 0.64	0.30	0.094	–	1.000
Late	− 0.67	0.36	0.097	1.000	–
Total	− 0.6	0.37		0.051
Language
Early	− 0.36	0.48	–	0.737	0.037
Average	− 0.5	0.60	0.737	–	0.245
Late	− 0.74	0.64	0.037	0.245	–
Total	− 0.52	0.59		0.042
Praxis
Early	− 0.6	0.87	–	0.036	0.08
Average	− 0.99	0.64	0.036	–	1.000
Late	− 1.01	0.62	0.080	1.000	–
Total	− 0.89	0.73		0.026