Table 1.
Details of human iPSC control and C9orf72 lines
| Line | Reprogramming method | Repeat Length | Sex | Ethnicity | Age of onset (years) | Age at skin biopsy (years) | Disease duration (months) | Diagnosis | Family history | Site of onset | Dementia |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Con-1 | Retroviral | N/A | Female | Unknown | N/A | 40 | N/A | N/A | N/A | No | |
| Con-2 | Episomal | N/A | Female | Caucasian | N/A | 56 | N/A | N/A | Psychiatric disorders | N/A | No |
| C9-1 | Sendai | c. 750 | Female | Dutch | 38 | 39 | 31 | ALS/FTD (pm confirmed) | ALS/FTD | Behavioural change, language loss, wasting of hand muscles | Yes |
| C9-2 | Retroviral | c. 638 | Male | Caucasian | 52 | 58 | 72 | ALS | Mother-dementia | Lower limb | Cognitive decline |
| C9-3 | Retroviral | c. 960 | Male | Dutch | 65 | 67 | 36 | ALS | ALS/FTD | Lower limb | No |