Table 2.
Clinical meta-data for C9orf72 cases used in post-mortem work
| Case ID (sex) | Age at death (years) | Disease duration (months) | Regions affected at death | Classification based on El Escorial criteria[60] | Past medical history | Smoker | Alcohol intake | Prescribed riluzole |
|---|---|---|---|---|---|---|---|---|
| Case 1 (F) | 63 | 25 | UL and LL | Amyotrophic lateral sclerosis (definite) | Migraine | Ex | Yes | No |
| Case 2 (M) | 50 | 29 | UL, LL and bulbar | Amyotrophic lateral sclerosis (probable) | Sarcoidosis | Ex | No | Yes |
| Case 3 (F) | 62 | 37 | UL, LL and bulbar | Amyotrophic lateral sclerosis (definite) | Lumbar discectomy | Yes | Yes | Yes |
| Case 4 (F) | 62 | 50 | UL, LL and bulbar | Amyotrophic lateral sclerosis (definite) | Nil known | No | Yes | No |
| Case 5 (M) | 58 | 87 | UL and LL | Amyotrophic lateral sclerosis (definite) | Lower back pain | Yes | Yes | Yes |
UL upper limb, LL lower limb, F female, M male