Table 4.
Characteristics of MOS participants (n = 2644) at interim analysis
| Mean (SD) or % | Generation 2 | Generation 3 | Men | Women | |
|---|---|---|---|---|---|
| Age (years) | 39.8 (13.9) | 51.5 (8.1) | 27.9 (6.7) | ||
| Sex (% women) | 52.1 | 52.3 | 52.1 | ||
| BMI (kg/m2) | 25.8 (4.7) | 26.8 (4.7) | 24.9 (4.6) | 26.6 (4.4) | 25.1(4.9) |
| Waist circumference (m) | 0.85 (0.09) | 0.93 (0.13) | 0.86 (0.12) | 0.95 (12.8) | 0.84 (12.42) |
| Fasting glucose (mmol/L) | 5.48 (1.05) | 5.7 (1.28) | 5.3 (0.73) | 5.57 (1.2) | 5.4 (0.9) |
| LDL cholesterol (mmol/L) | 3.13 (0.94) | 3.42 (0.95) | 2.83 (0.84) | 3.27 (0.99) | 3.0 (0.9) |
| HDL cholesterol (mmol/L) | 1.61 (0.48) | 1.66 (0.52) | 1.57 (0.44) | 1.41 (0.39) | 1.80 (0.48) |
| Triglycerides (mmol/L) | 1.12 (0.69) | 1.28 (1.57) | 1.01 (0.58) | 1.32 (1.32) | 0.99 (0.53) |
| Systolic Blood Pressure (mmHg) | 115 (15) | 121 (16) | 111 (11) | 121 (12) | 112 (15) |
| Diastolic Blood Pressure (mmHg) | 71 (10) | 76 (10) | 67 (7) | 72 (10) | 71 (10) |
| Medical history | |||||
| Any prescribed drug (%) | 37.1 | 45.8 | 27.4 | 24.3 | 35.9 |
| Antibiotics use the last 6 months (%) | 14.2 | 11.7 | 17 | 11.1 | 16.9 |
| Prevalent diabetes (n) | 85 | 69 | 16 | 53 | 32 |
| Prevalent cancer (n)* | 192 | 149 | 45 | 31 | 161 |
| Prevalent CVD events (n)** | 38 | 34 | 4 | 22 | 16 |
| Lifestyle, education | |||||
| Physical activity at work (%) | |||||
| Very light | 44 | 48.4 | 39 | 45.7 | 42.1 |
| Light | 15.2 | 17.2 | 12.8 | 13.3 | 17 |
| Moderate | 24.7 | 22.5 | 27.2 | 19.6 | 29 |
| Heavy | 12.9 | 9.8 | 26.4 | 14.7 | 11.3 |
| Very heavy | 3.3 | 2.1 | 4.6 | 6.7 | 0.6 |
| Leisure physical activity (%) | |||||
| Sedentary | 9 | 9.5 | 8.4 | 10.1 | 8.1 |
| Low | 37.5 | 40.2 | 34.4 | 34.9 | 40.1 |
| Moderate | 27.9 | 28.1 | 27.7 | 27 | 28.5 |
| High | 25.6 | 22.3 | 29.5 | 28 | 23 |
| Smoking (%) | |||||
| Regular smokers | 7 | 6.9 | 7 | 5.5 | 8.2 |
| Irregular smokers | 9.8 | 5.8 | 14 | 10.7 | 9 |
| Ex-Smokers | 24.2 | 33.4 | 14.6 | 33.4 | 25.8 |
| Never smokers | 59 | 53.9 | 64.4 | 61.4 | 57 |
| Snuff use (%) | |||||
| Ever used daily snuff | 19.9 | 21.6 | 18 | 36 | 6.1 |
| Alcohol intake (%) | |||||
| Never | 7.1 | 6.7 | 7.6 | 5.7 | 8.4 |
| 1/month | 22 | 17.6 | 27.4 | 16 | 27.1 |
| 2–4/month | 41.3 | 36.1 | 47 | 43.9 | 39.3 |
| 2–3/week | 25.7 | 34.8 | 16.3 | 29.1 | 22.8 |
| > 4/week | 3.8 | 5.8 | 1.6 | 5.3 | 2.4 |
| Education level (%) | |||||
| Basic < 9 years | 0.2 | 0.18 | 0.3 | 0.19 | 0.33 |
| Primary school 9–12 years | 6.8 | 8.7 | 4.6 | 7.1 | 6.7 |
| High school | 55.1 | 50.5 | 60.2 | 62.3 | 50.1 |
| University | 37.9 | 40.6 | 34.9 | 30.5 | 42.8 |
Means (SD) and proportions (%)
LDL: low density lipoprotein; HDL: high density lipoprotein
*prevalent tumours at baseline
**CVD event = cardiovascular event (myocardial infarction and/or stroke)