Figure 4.

Schisandrin C downregulated the Swiprosin-1/IFN-γ-Rβ signaling pathway in the right kidneys of DN model mice. DN model mice were treated with saline, Schisandrin C (100 or 200 mg/kg/d), or Metformin (195 mg/kg/d), for 8 weeks. A. Swiprosin-1 and IFN-γRβ expression levels were analyzed by western blot analysis, using β-actin as a loading control. B. p-JAK2, p-STAT1, and p-STAT3 expression levels were analyzed by western blot analysis, using β-actin as a loading control. Representative blots are shown, with densitometry analysis. Original full-size blots are presented in Figure S1. Data are expressed as the mean ± S.D. ##P < 0.01 vs. control; **P < 0.01, *P < 0.05 vs. model.