Table 2.

Multivariate analysis for OS and CSS before PSM

Characteristics	OS		CSS
	HR (95% CI)	P value	HR (95% CI)	P value
Age (Years)
30-49	Reference		Reference
50-69	0.495 (0.288, 0.849)	0.011	0.561 (0.302, 1.042)	0.067
70-84	0.508 (0.285, 0.904)	0.032	0.627 (0.273, 1.017)	0.056
Gender
Male	Reference		Reference
Female	0.647 (0.471, 0.889)	0.007	0.672 (0.457, 0.989)	0.044
Race
White	Reference		Reference
Black	1.584 (1.068, 2.348)	0.022	1.377 (0.824, 2.301)	0.222
Other	0.712 (0.470, 1.079)	0.109	0.654 (0.399, 1.074)	0.093
Year of diagnosis
2004-2007	Reference		Reference
2008-2011	0.728 (0.518, 1.023)	0.067	0.679 (0.457, 1.009)	0.055
2012-2015	0.744 (0.553, 1.086)	0.138	0.624 (0.414, 0.939)	0.024
Marital status
Married	Reference		Reference
Single	0.849 (0.635, 1.134)	0.268	0.880 (0.621, 1.248)	0.474
Other	0.839 (0.635, 1.425)	0.515	0.924 (0.516, 1.656)	0.791
AJCC staging
I	Reference		Reference
II	1.126 (0.777, 1.632)	0.530	1.133 (0.726, 1.769)	0.581
III	2.085 (1.445, 3.008)	<0.001	1.724 (1.113, 2.671)	0.015
IV	5.370 (3.437, 8.390)	<0.001	5.046 (3.012, 8.455)	<0.001
Unknown	0.909 (0.522, 1.581)	0.735	0.900 (0.448, 1.808)	0.767
Tumor number
1	Reference		Reference
2	1.209 (0.862, 1.377)	0.271	0.786 (0.372, 1.659)	0.527
3	0.882 (0.437, 1.778)	0.725	N
>3	0.553 (0.129, 2.371)	0.425	N
Chemotherapy
Yes	Reference		Reference
No/Unknown	1.054 (0.807, 1.377)	0.699	1.024 (0.749, 1.401)	0.880
Surgery
Transplantation	Reference		Reference
Liver resection	2.613 (1.541, 4.431)	<0.001	3.589 (1.859, 6.928)	<0.001
Non-liver resection	3.711 (2.224, 6.192)	<0.001	5.447 (2.862, 10.367)	<0.001
Radiotherapy
Internal radiotherapy	Reference		Reference
External radiotherapy	1.393 (1.046, 1.856)	0.023	1.409 (1.000, 1.987)	0.050
Internal and external radiotherapy	1.041 (0.318, 3.408)	0.947	1.339 (0.393, 4.565)	0.640
Unknown	0.691 (0.321, 1.487)	0.345	0.600 (0.230, 1.565)	0.297
Time of radiotherapy
Pre-surgery	Reference		Reference
Post-surgery	1.785 (1.295, 2.461)	<0.001	1.928 (1.316, 2.824)	0.001