Table 2.
Comparison of selected parameters
| Group A (LGE + , EF < 50%) n = 8 | Group B (LGE + , EF ≥ 50%) n = 13 | Group C (LGE-, EF ≥ 50%) n = 30 | Controls n = 18 | p | |
|---|---|---|---|---|---|
| Age (years) | 20.6 ± 6.1 | 15.1 ± 4.8 | 13.0 ± 5.8* | 17.5 ± 2.9 | 8.10–4 |
| Weight (kg) | 68.0 ± 19.9 | 52.6 ± 23.4* | 42.1 ± 15.8* | 68.1 ± 10.5 | 6.10–6 |
| Height (cm) | 166 ± 12 | 152 ± 19* | 143 ± 18* | 177 ± 18 | 1.10–9 |
| BMI (kg/m2) | 24.4 ± 5.9 | 22.4 ± 7.6 | 19.9 ± 4.1 | 21.8 ± 2.2 | 0.09 |
| Dyspnoea (n (%)) | 3 (37.5%)* | 3 (23.1%) | 1 (3.5%) | 0 (0%) | 7.10–3 |
| Hypertension (n (%)) | 3 (37.5%)* | 0 (0%) | 0 (0%) | 0 (0%) | 3.10–6 |
| Diabetes (n (%)) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (5.6%) | 0.42 |
| Corticosteroids (n (%)) | 1 (12.5%) | 6 (46.2%)* | 15 (50.0%)* | 0 (0%) | 8.10–4 |
| ACE-inhibitors (n (%)) | 5 (62.5%)* | 8 (61.5%)* | 5 (17.9%) | 0 (0%) | 1.10–4 |
| ARBs (n (%)) | 2 (25.0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1.10–3 |
| β-blockers (n (%)) | 6 (75.0%)* | 1 (7.7%) | 1 (3.6%) | 0 (0%) | 1.10–7 |
| Diuretics (n (%)) | 3 (37.5%)* | 0 (0%) | 0 (0%) | 0 (0%) | 4.10–6 |
| LV EF (%) | 37.9 ± 9.9* | 61.2 ± 7.1 | 64.9 ± 6.8 | 66.3 ± 7.2 | 1.10–13 |
| LVMi (g/m2) | 59.2 ± 12.9 | 41.8 ± 7.7* | 33.5 ± 7.6* | 53.6 ± 13.0 | 3.10–11 |
| LV EDVi (ml/m2) | 88.5 ± 29.6* | 47.9 ± 8.5* | 52.4 ± 13.0* | 64.8 ± 11.6 | 8.10–9 |
| LV ESVi (ml/m2) | 55.9 ± 23.9* | 18.7 ± 5.12 | 19.1 ± 7.2 | 21.6 ± 4.4 | 7.10–14 |
| LV SVi (ml/m2) | 32.6 ± 9.5* | 29.1 ± 5.4* | 32.8 ± 8.2* | 43.3 ± 10.4 | 1.10–5 |
Continuous variables are expressed as the mean ± standard deviation; categorical as total count (percentage)
Variables marked in bold have their ANOVA/χ2 test p value < 0.05
*denotes a significant difference compared with the control group (Dunnet post hoc test or a series of 3 Fisher exact tests with Bonferroni correction)
BMI, body mass index (kg/m2); ACE, angiotensin converting enzyme; ARB, angiotensin receptor blockers; LGE + , positive late gadolinium enhancement; LGE–, negative late gadolinium enhancement; LV, left ventricle; EF, ejection fraction; LVMi, left ventricular mass index; EDVi, end-diastolic volume index; ESVi, end-systolic volume index; SVi, stroke volume index