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. 2021 Jan 1;18(5):1143–1152. doi: 10.7150/ijms.52256

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Schematic workflow illustrating the study design. Severe acute respiratory syndrome coronavirus (SARS-CoV)-2-infected ACE2-expressed-A549 and normal human bronchial epithelial (NHBE) cells were acquired from the GSE147507 dataset in the National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO) databases. Highly expressed genes were merged in a Venn diagram analysis. Shared genes from the two datasets were analyzed by the DAVID, GO, IPA, and GSEA. Abbreviation: ACE2, angiotensin-converting enzyme 2; DAVID, Database for Annotation, Visualization, and Integrated Discovery; GO, gene ontology; GSEA, Gene Set Enrichment Analysis; IPA, ingenuity pathway analysis; NHBE cells, normal human bronchial epithelial cells; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.