Table 3.
Univariate and multivariate analyses of clinical items and cirrhosis in patients with CHB (n=161)
| Variables | Cirrhosis (F4) | |||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age, years | 1.02 (1.00-1.04) | 0.014 | ---- | ---- |
| Gender, male | 1.55 (1.03-2.33) | 0.036 | ---- | ---- |
| MAFLD, yes vs. no | 0.36 (0.16-0.82) | 0.014 | ---- | ---- |
| AST, U/L | 1.00 (1.00-1.00) | 0.001 | ---- | ---- |
| ALP, U/L | 1.01 (1.00-1.02) | < 0.001 | ---- | ---- |
| GGT, U/L | 1.00 (1.00-1.01) | 0.001 | ---- | ---- |
| DBil, µmol/L | 1.05 (1.03-1.07) | < 0.001 | ---- | ---- |
| Prealbumin, g/L | 0.99 (0.99-1.00) | < 0.001 | ---- | ---- |
| Albumin, g/L | 0.84 (0.80-0.88) | < 0.001 | 0.89 (0.83-0.97) | 0.006 |
| Cholinesterase, U/L | 0.99 (0.99, 1.00) | < 0.001 | 1.00 (0.99-1.00) | 0.001 |
| Total bile acid, µmol/L | 1.02 (1.01, 1.03) | < 0.001 | ---- | ---- |
| TC, mmol/L | 0.57 (0.45-0.73) | < 0.001 | ---- | ---- |
| LDL, mmol/L | 0.59 (0.45-0.77) | < 0.001 | ---- | ---- |
| HDL, mmol/L | 0.45 (0.27-0.73) | 0.001 | ---- | ---- |
| Globulin, g/L | 1.08 (1.04-1.12) | < 0.001 | ---- | ---- |
| INR | 3.15 (2.46-4.04) | < 0.001 | 2.52 (1.72-3.68) | < 0.001 |
| WBC count, ×109/L | 0.78 (0.69-0.90) | < 0.001 | ---- | ---- |
| Platelet count, ×109/L | 0.97 (0.96-0.97) | < 0.001 | 0.97 (0.96-0.98) | < 0.001 |
| Hemoglobin, g/L | 0.99 (0.98-1.00) | 0.045 | ---- | ---- |
| Neutrophil count, ×109/L | 0.69 (0.57-0.84) | < 0.001 | ---- | ---- |
| RBC count, ×1012/L | 0.47 (0.33-0.65) | < 0.001 | ---- | ---- |
Variables including age, sex, MAFLD, HBsAg quantity, HBeAg status, HBVDNA, ALT, AST, ALP, GGT, TBil, DBil, prealbumin, albumin, cholinesterase, total bile acid, FBG, TC, TG, LDL, HDL, urea, creatinine, eGFR, INR, WBC, RBC, platelet, neutrophil, and hemoglobin were included in the univariate model.
Only variables significantly associated with cirrhosis in univariate analysis were presented and enrolled in multivariate model.