Table 4.

Predictive values of INPR, APRI, FIB-4 and GPR for liver fibrosis in CHB patients

	F2-4 (n = 364)		F3-4 (n = 254)		F4 (n = 161)
	Estimate	95%CI	Estimate	95%CI	Estimate	95%CI
INPR
AUROC	0.74	0.70-0.78	0.76	0.72-0.79	0.86	0.83-0.90
Cutoff	0.69	-	0.72		0.83	-
Sen (%)	57.62	52.3-62.8	67.06	60.9-72.9	68.75	61.0-75.8
Spe (%)	80.34	73.7-85.9	75.61	70.2-80.5	87.07	83.3-90.3
PPV (%)	85.6	81.3-89.0	70.7	65.9-75.1	69.2	62.9-74.8
NPV (%)	48.3	44.8-51.8	72.3	68.4-75.9	86.8	83.9-89.3
DA (%)	64.9		71.4		81.3
APRI
AUROC	0.77	0.73-0.80	0.70	0.66-0.74	0.74	0.71-0.78
Cutoff	0.66	-	0.69		0.69	-
Sen (%)	71.15	66.2-75.8	73.23	67.3-78.6	83.23	76.5-88.6
Spe (%)	72.63	65.5-79.0	59.52	53.6-65.2	55.76	50.6-60.8
PPV (%)	84.10	80.5-87.1	61.4	57.6-65.1	44.2	41.0-47.5
NPV (%)	55.30	50.7-59.8	71.7	66.9-76.0	88.7	84.7-91.8
DA (%)	71.6		65.5		67.4
FIB-4
AUROC	0.72	0.68-0.75	0.71	0.67-0.74	0.80	0.76-0.83
Cutoff	1.56	-	1.65		2.33	-
Sen (%)	56.59	51.3-61.8	59.84	53.5-65.9	60.87	52.9-68.5
Spe (%)	78.21	71.4-84.0	73.36	67.9-78.4	86.13	82.2-89.4
PPV (%)	84.1	79.8-87.6	66.4	61.4-71.0	64.9	58.3-71.0
NPV (%)	47.0	43.5-50.5	67.5	63.8-71.0	83.9	81.1-86.4
DA (%)	63.3		66.6		78.4
GPR
AUROC	0.75	0.70-0.78	0.74	0.71-0.78	0.80	0.76-0.83
Cutoff	0.20		0.25		0.38
Sen (%)	74.45	69.6-78.9	74.80	69.0-80.0	75.16	67.7-81.6
Spe (%)	68.72	61.4-75.4	66.44	60.7-71.9	76.70	72.1-80.9
PPV (%)	82.9	79.4-85.8	66.2	62.1-70.0	57.6	52.6-62.5
NPV (%)	56.9	52.0-61.8	75.0	70.5-79.0	88.0	84.8-90.6
DA (%)	72.0		69.6		76.1

Sen, sensitivity; Spe, specificity; PPV, positive predictive value; NPV, negative predictive value; DA, diagnostic accuracy.