Table 2.

Prospective application of macrophage polarization in IRI management

Methods		Effect on molecular pathways	Effect on IRI
Fasudil carried liposomes		inhibiting the expression of ROCK-II in KCs	shifting the M1/M2 balance toward an anti-inflammatory profile; inhibiting the secretion of pro-inflammatory factors and promoting the secretion of anti-inflammatory factors; alleviating liver ischemia-reperfusion injury
P300 / CBP inhibitor A-485		inhibiting H3K27ac/H3K18ac at promoter regions of pivotal inflammatory genes
Curcumin		down-regulating NF-κb signaling pathway by stimulating PPARγ
Epigenetics and non-coding Mi-RNA	MicroRNA-155	reducing the expression of CD80, CD86 and major histocompatibility complex class II
	IncRNA	maintaining the activation of STAT6
preservation techniques of the liver	αKG	up-regulating the expression of p-GSK3β and SOCS1
	VEGF-C	up-regulating the expression of p-GSK3β and SOCS1