Table 5.

Logistic regression analysis for composite safety events within one year after stroke onset

Variables	Univariate analysis			Multivariate analysis
	OR	95% CI	P-value	OR	95% CI	P-value
Age (year)	0.922	0.873-0.973	0.003	0.897	0.838-0.960	0.002
Male	0.566	0.189-1.689	0.307
HA regimen	0.245	0.066-0.905	0.035	0.217	0.051-0.925	0.039
GCS score	1.208	0.959-1.520	0.108
NIHSS score	1.015	0.934-1.103	0.729
CHA2DS2-VASc	0.889	0.575-1.375	0.598
HAS-BLED	0.568	0.361-0.894	0.014
History
Hypertension	0.943	0.320-2.785	0.916
Coronary heart disease	0.366	0.099-1.350	0.131
Stroke	0.168	0.022-1.312	0.089
Diabetes mellitus	1.558	0.325-7.463	0.579
Hyperlipidemia	0.469	0.059-3.726	0.474
Cigarette smoking	1.020	0.329-3.156	0.973
Drinking	1.440	0.431-4.808	0.553
Previous anticoagulant use	4.022	1.296-12.478	0.016	6.355	1.690-23.892	0.006
Cholesterol level	0.698	0.415-1.176	0.177
Platelets level	1.001	0.988-1.015	0.844
Baseline coagulation indices
PT	0.483	0.236-0.989	0.046	0.328	0.136-0.789	0.013
TT	0.950	0.735-1.228	0.694
APTT	1.062	0.911-1.239	0.441
INR	0.970	0.678-1.389	0.869

Abbreviations: OR = odds ratio; CI = confidence interval; HA = hirudin plus aspirin; GCS = Glasgow Coma Scale; NIHSS = National Institute of Health Stroke Scale; CHA₂DS₂-VASc = congestive heart failure, hypertension, age ≥ 75 (doubled), diabetes, stroke (doubled), vascular disease, age 65-74 and sex category (female); HAS-BLED = hypertension, abnormal renal/liver function (1 point each), stroke, bleeding history or predisposition, labile international normalized ratio , elderly (>65), drugs/alcohol concomitantly (1 point each); PT = prothrombin time; TT = thrombin time; APTT = activated partial thromboplastin time; INR = international normalized ratio.