Table 2.
Association between ABCG2 SNPs and objective response
| Genotype | Panel A | Panel B | All | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Response (CR+PR/SD+PD) | P valuea | OR (95%CI)b | Response (CR+PR/SD+PD) | P value a | OR (95%CI)b | Response (CR+PR/SD+PD) |
P valuea | OR (95%CI)b | |
| rs2231164 | |||||||||
| A/A | 16/51 | 0.274 | 1.00 (ref) | 33/173 | 0.028 | 1.00 (ref) | 49/224 | 0.035 | 1.00 (ref) |
| A/G | 16/92 | 0.54 (0.23-1.26) | 60/316 | 1.09(0.68-1.77) | 76/408 | 0.89 (0.59-1.34) | |||
| G/G | 12/47 | 0.77 (0.31-1.95) | 40/119 | 1.94 (1.13-3.32) | 52/166 | 1.47 (0.93-2.32) | |||
| G/G vs A/A+A/G | 32/143 | 0.528 | 1.12 (0.51-2.46) | 93/489 | 0.008 | 1.83 (1.17-2.84) | 125/632 | 0.013 | 1.58 (1.08-2.32) |
| rs4148157 | |||||||||
| G/G | 23/100 | 0.433 | 1.00 (ref) | 63/335 | 0.036 | 1.00 (ref) | 86/435 | 0.043 | 1.00 (ref) |
| G/A | 16/75 | 0.69 (0.32-1.53) | 57/245 | 1.35 (0.90-2.04) | 73/320 | 1.17 (0.82-1.68) | |||
| A/A | 5/15 | 1.86 (0.57-6.05) | 13/28 | 2.65(1.23-5.70) | 18/43 | 2.12 (1.13-4.00) | |||
| A/A vs G/G+G/A | 39/175 | 0.458 | 2.19 (0.71-6.75) | 120/580 | 0.018 | 2.31 (1.11-4.84) | 159/755 | 0.017 | 2.00 (1.08-3.71) |
| rs1871744 | |||||||||
| A/A | 25/98 | 0.023 | 1.00 (ref) | 77/279 | 0.042 | 1.00 (ref) | 102/377 | 0.022 | 1.00 (ref) |
| A/G | 9/72 | 0.51 (0.21-1.23) | 44/254 | 0.59 (0.39-0.91) | 53/326 | 0.59 (0.41-0.86) | |||
| G/G | 10/20 | 2.35 (0.87-6.31) | 12/75 | 0.59 (0.30-1.18) | 22/95 | 0.92 (0.54-1.58) | |||
| A/G vs A/A+G/G | 35/118 | 0.022 | 0.43 (0.18-0.99) | 91/362 | 0.064 | 0.65 (0.43-0.98) | 124/472 | 0.007 c | 0.60 (0.42-0.87) |
| rs2231142 | |||||||||
| C/C | 21/89 | 0.618 | 1.00 (ref) | 55/292 | 0.002 | 1.00 (ref) | 76/381 | 0.005 c | 1.00 (ref) |
| C/A | 17/80 | 0.83 (0.39-1.78) | 55/270 | 1.17 (0.76-1.79) | 72/350 | 1.07 (0.74-1.54) | |||
| A/A | 6/21 | 1.13 (0.37-3.43) | 23/46 | 2.96 (1.59-5.45) | 29/67 | 2.14 (1.26-3.63) | |||
| A/A vs C/C+C/A | 38/169 | 0.348 | 1.24 (0.44-3.51) | 110/562 | 4.71×10-4 | 2.73 (1.53-4.85) | 148/731 | 0.001 c | 2.07 (1.26-3.63) |
a P values of Pearson χ2 tests.
b Odds ratios (OR) and their 95% confidence intervals (CIs) and P values were calculated with unconditional logistic regression analysis, with adjustment of gender, age, smoking status, ECOG performance status, TNM status, histological types, and treatment regimen.
c Statistical significance remained after multiple tests adjustment taking into account linkage disequilibrium between polymorphisms.