Table 5.
Association between ABCG2 SNPs and overall survival
| Genotype | Panel A | Panel B | All | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n/Na | MST (m)b | Log-rank P | HR (95% CI)c | n/Na | MST (m)b | Log-rank P | HR (95% CI)c | n/Na | MST (m)b | Log-rank P | HR (95% CI)c | |
| rs2231164 | ||||||||||||
| A/A | 47/65 | 22.4 | 0.025 | 1.00 (ref) | 152/205 | 19.1 | 0.383 | 1.00 (ref) | 199/270 | 20.7 | 0.039 | 1.00 (ref) |
| A/G | 79/104 | 19.3 | 1.36 (0.92-2.00) | 276/379 | 18.8 | 1.01 (0.83-1.24) | 355/483 | 19.0 | 1.08 (0.91-1.29) | |||
| G/G | 47/59 | 15.8 | 1.86 (1.18-2.94) | 127/160 | 18.2 | 1.15 (0.91-1.47) | 174/219 | 18.0 | 1.26 (1.02-1.55) | |||
| rs4148157 | ||||||||||||
| G/G | 84/118 | 21.8 | 0.018 | 1.00 (ref) | 287/402 | 19.0 | 0.120 | 1.00 (ref) | 371/520 | 20.4 | 0.008d | 1.00 (ref) |
| G/A | 72/90 | 15.6 | 1.35 (0.95-1.92) | 236/300 | 18.9 | 1.20 (1.00-1.43) | 308/390 | 17.9 | 1.21 (1.04-1.42) | |||
| A/A | 17/0 | 15.1 | 1.67 (0.95-2.93) | 32/42 | 20.2 | 1.14 (0.78-1.66) | 49/62 | 17.0 | 1.25 (0.92-1.70) | |||
| G/A+A/A vs G/G | 89/110 | 15.4 | 0.006 | 1.40 (1.01-1.96) | 268/342 | 18.9 | 0.040 | 1.19 (1.01-1.41) | 357/452 | 17.9 | 0.002 | 1.22 (1.05-1.42) |
| rs12505410 | ||||||||||||
| A/A | 92/114 | 18.7 | 0.083 | 1.00 (ref) | 245/327 | 17.0 | 0.350 | 1.00 (ref) | 337/441 | 17.1 | 0.064 | 1.00 (ref) |
| A/C | 60/85 | 21.4 | 0.73 (0.51-1.04) | 241/327 | 19.7 | 0.85 (0.71-1.03) | 301/412 | 20.7 | 0.84 (0.72-0.99) | |||
| C/C | 21/29 | 21.5 | 0.82 (0.49-1.36) | 69/90 | 22.2 | 0.78 (0.59-1.03) | 90/119 | 21.6 | 0.77 (0.61-0.96) | |||
| rs2231142 | ||||||||||||
| C/C | 76/106 | 21.7 | 0.025 | 1.00 (ref) | 248/327 | 19.0 | 0.326 | 1.00 (ref) | 327/452 | 20.4 | 0.043 | 1.00 (ref) |
| C/A | 73/95 | 15.4 | 1.49 (1.05-2.10) | 248/329 | 18.9 | 1.06 (0.88-1.27) | 321/422 | 17.9 | 1.14 (0.97-1.33) | |||
| A/A | 24/27 | 21.2 | 1.46 (0.88-2.42) | 60/76 | 16.5 | 1.21 (0.90-1.63) | 80/98 | 19.6 | 1.27 (0.99-1.64) | |||
| C/A+A/A vs C/C | 97/122 | 16.6 | 0.007 | 1.48 (1.07-2.06) | 308/405 | 18.9 | 0.336 | 1.08 (0.91-1.29) | 401/520 | 18.0 | 0.028 | 1.16 (1.00-1.35) |
a Numbers indicate the death event for NSCLC patients during the following-up time among all individuals in the same genotype group.
bMST: median survival time.
cHazard ratios (HR) and their 95% confidence intervals (CIs) and P values were calculated with by multivariate Cox proportional hazards regression with adjustment for covariates.
d Statistical significance remained after Bonferroni multiple tests.