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. 2021 Jan 1;12(5):1507–1519. doi: 10.7150/jca.50293

Figure 4.

Figure 4

Effect of p53 expression on BRD7 inhibition of migration, invasiveness and cell cycle in HCC cells. (A) Transwell migration assay for Bel7402 cells co-transfected with vector and siControl, BRD7 and siControl, or BRD7 and sip53, respectively. (B) Transwell migration assay for HepG2 cells co-transfected with siControl and vector, siBRD7 and vector, or siBRD7 and p53, respectively. (C) Matrigel invasion assay for each group of the Bel7402 cells. (D) Matrigel invasion assay for each group of the HepG2 cells. Images are shown in the left panel at 100× magnification; the quantification of 6 randomly selected fields is shown in the right panel. (E) Cell cycle assay of Bel7402 cells co-transfected with vector and siControl, BRD7 and siControl, or BRD7 and sip53, respectively. (F) Cell cycle assay of HepG2 cells co-transfected with siControl and vector, siBRD7 and vector, or siBRD7 and p53, respectively. All experiments were performed in triplicate. The mean ± SD of the foci for each group are shown. * p<0.05, ** p<0.01, *** p<0.001.