Table 2.

Multivariate Cox regression analyses of iPFS and OS

Variable	iPFS			OS
	P-value	HR	95%CI	P-value	HR	95%CI
EGFR Mutation	0.864	0.98	0.81-1.2	0.428	0.92	0.75-1.13
Smoking	0.422	1.14	0.83-1.57	0.718	1.06	0.77-1.46
Histology	0.032	0.54	0.31-0.95	<0.001	0.29	0.16-0.51
Number of BM	<0.001	1.97	1.47-2.66	<0.001	2.22	1.65-2.98
Extracranial metastases	0.001	1.67	1.24-2.24	<0.001	2.17	1.58-2.98
Radiation therapy	0.387	0.91	0.74-1.12	0.956	1	0.81-1.22
TKI	0.04	0.86	0.74-1.0	0.072	1.15	0.99-1.33