Figure 6.

Schematic illustration of a positive feedback loop for the role of c-Myc/miR-21/Mxd1 in B cell lymphoma. A. c-Myc activation or overexpression enhances miR-21 expression, miR-21 in turn targets Mxd1 mRNA and down-regulates Mxd1 protein; and finally decreased Mxd1 promotes formation of c-Myc-Max heterodimer, leading to sustained c-Myc activation. B. Following NL101 treatment, the expression of miR-21 is decreased and Mxd1 is up-regulated, resulting in inhibition of c-Myc activity and further decreased expression of miR-21; thus, by targeting miR-21 to block c-Myc/miR-21/Mxd1 loop, NL101 can efficiently inhibit the growth of B cell lymphoma.