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. 2021 Jan 1;11(7):3060–3073. doi: 10.7150/thno.54150

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CNAs of enhancers regulate cancer-related genes. (A) The framework for identifying genes potentially regulated by enhancers. (B) Circos plots showing the enhancer-gene regulation in glioma. Red regions for enhancers with copy number amplification, blue regions for enhancers with copy number deletion, and green regions for genes regulated by CNV-driven enhancers. (C) Numbers of genes regulated by enhancers in glioma. Bar plots showing the number of genes. Venn plots showing the overlaps of target genes regulated by amplified or deleted enhancers. (D) Pathways enriched by target genes of enhancers. Red for genes regulated by amplified enhancers and blue for genes regulated by deleted enhancers. (E) Proportion of cancer genes in target genes regulated by enhancers. The significance levels were calculated by comparison with randomly selected genes.