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. 2021 Jan 1;11(7):3060–3073. doi: 10.7150/thno.54150

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CNAs and enhancers cooperatively regulate the expression of genes. (A) Number of genes regulated by different number of enhancers in glioma. (B) The expression of genes regulated by different number of amplified enhancers. (C) The expression of genes regulated by different number of deleted enhancers. (D) Regulatory models proposed for CNAs and enhancers cooperative regulation. (E) The expression differences for genes in different amplified models. (F) The expression differences for genes in different deleted models.