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Biogenesis, secretion, and cellular entry of exosomes. (A) Exosomes develop within MVBs and are released by fusion with the plasma membrane. (B) Exosomes enter cells through three main pathways: (a) membrane fusion with the target cell, (b) internalization driven by receptor-ligand interactions, and (c) endocytosis. LE, late endosome; MVB, multivesicular body. Adapted with permission from 24, copyright 2014 Elsevier.
