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. 2021 Jan 1;11(7):3109–3130. doi: 10.7150/thno.53474

Figure 4.

Figure 4

Nasally administered mitochondria enter the brain. (A) Representation of mouse brain sagittal section with ROIs depicting where mitochondria were detected; scale bar 2500 µm. Nasally administered DsRed+/anti-human mitochondria+ mitochondria (yellow) were detected in (B) Ventricle; scale bar 100 µm (C) RMS - DsRed+ (green)/anti-human mitochondria+ (red) mitochondria (yellow) internalized by GFAP+ cells (magenta) in the RMS; scale bars 25 and 10 µm (D) Choroid Plexus (E) Hippocampus (F) Olfactory bulb; scale bars 25 and 50 µm.