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. 2021 Jan 1;11(7):3109–3130. doi: 10.7150/thno.53474

Figure 6.

Figure 6

Nasally administered mitochondria repair cisplatin-damaged white matter integrity. (A) Mouse brain coronal section stained with Black Gold II with ROI indicating the cingulate cortex where white matter integrity was analysed; scale bar 1000 µm. Cisplatin-treatment (B) reduced percent area stained with Black Gold II and (C) increased coherency index which inversely relates to the complexity of myelin organization. Nasal administration of mitochondria reversed this damage. (D) Low magnification (4x) images representing Black Gold II+ area; scale bar 100 µm. (E) Higher magnification images (20x) representing the myelin organization; scale bar 25 µm. (F) Skeletonization of these higher magnification images revealed the complexity of the myelin arborization; scale bar 25 µm. Results are expressed as mean ± SEM; n = 4-8; Two-way ANOVA with Tukey's post hoc analysis **p ≤ 0.01; *** p ≤ 0.001; **** p ≤ 0.0001.