Figure 8.

Nasally administered mitochondria resolve cisplatin-induced synaptosomal mitochondrial defects and membrane integrity. (A) Representative TEM images depicting the ultrastructure of mitochondria in brain synaptosomes for different treatment groups. Mitochondrial swelling, membrane ruffling and cristae disorganization indicate defective or atypical mitochondria; scale bar 100 nm. (B) Representative TEM images showing whole synaptosomes. Membrane ruffling and disruption, blebs and vesicle leakage were considered to indicate compromised membrane integrity; scale bar 100 nm. Synaptosomes of cisplatin-treated mice revealed (C) high percentage of atypical mitochondria and (D) high percentage of damaged synaptic membrane. Results are expressed as mean ± SEM; n = 4; Two-way ANOVA with Tukey's post hoc analysis *p ≤ 0.05; **p ≤ 0.01.