Table 1.
Oncogenic proteins/growth-promoting regulators and tumor suppressors/growth-inhibitory regulators as Pin1 substrates
| Substrate | Function | Activity of substrate | Refs |
|---|---|---|---|
| AIB1 | Oncogenic protein | ↑ | 158 |
| AKT | Oncogenic protein | ↑ | 159 |
| BCL2 | Oncogenic protein | ↑ | 160 |
| JUN | Oncogenic protein | ↑ | 23 |
| COX2 | Oncogenic protein | ↑ | 161 |
| FOS | Oncogenic protein | ↑ | 162 |
| FOXM1 | Oncogenic protein | ↑ | 163 |
| HER2 | Oncogenic protein | ↑ | 164 |
| MYC | Oncogenic protein | ↑ | 165 |
| Survivin | Oncogenic protein | ↑ | 46 |
| Tax | Oncogenic protein | ↑ | 118 |
| XBP1 | Oncogenic protein | ↑ | 166 |
| AR | Growth-promoting regulator | ↑ | 167 |
| CDC25 | Growth-promoting regulator | ↑ | 168 |
| Cep55 | Growth-promoting regulator | ↑ | 169 |
| MYB | Growth-promoting regulator | ↑ | 170 |
| Cyclin D1 | Growth-promoting regulator | ↑ | 23 |
| ER | Growth-promoting regulator | ↑ | 164 |
| FAK | Growth-promoting regulator | ↑ | 171 |
| HBx | Growth-promoting regulator | ↑ | 113 |
| HIF1 | Growth-promoting regulator | ↑ | 172 |
| HSF1 | Growth-promoting regulator | ↑ | 173 |
| IRAK1 | Growth-promoting regulator | ↑ | 174 |
| MCL1 | Growth-promoting regulator | ↑ | 175 |
| Nanog | Growth-promoting regulator | ↑ | 176 |
| NF-κB | Growth-promoting regulator | ↑ | 177 |
| NOTCH1 | Growth-promoting regulator | ↑ | 178 |
| NOTCH3 | Growth-promoting regulator | ↑ | 179 |
| NUR77 | Growth-promoting regulator | ↑ | 180 |
| OCT4 | Growth-promoting regulator | ↑ | 181 |
| p47phox | Growth-promoting regulator | ↑ | 182 |
| p53M | Growth-promoting regulator | ↑ | 183 |
| PGK1 | Growth-promoting regulator | ↑ | 115 |
| PKM2 | Growth-promoting regulator | ↑ | 184 |
| PLK | Growth-promoting regulator | ↑ | 185 |
| PML-RARα | Growth-promoting regulator | ↑ | 186 |
| PTP | Growth-promoting regulator | ↑ | 187 |
| PTP-PEST | Growth-promoting regulator | ↑ | 171 |
| RAB2A | Growth-promoting regulator | ↑ | 188 |
| RAF1 | Growth-promoting regulator | ↑ | 189 |
| RSK2 | Growth-promoting regulator | ↑ | 190 |
| S642 | Growth-promoting regulator | ↑ | 189 |
| S6K | Growth-promoting regulator | ↑ | 191 |
| Separase | Growth-promoting regulator | ↑ | 192 |
| SEPT9 | Growth-promoting regulator | ↑ | 193 |
| BRD4 | Growth-promoting regulator | ↑ | 45 |
| STAT3 | Growth-promoting regulator | ↑ | 146 |
| v-Rel | Growth-promoting regulator | ↑ | 194 |
| β-catenin | Growth-promoting regulator | ↑ | 151 |
| BAX | Tumor suppressor | ↓ | 47 |
| CDK10 | Tumor suppressor | ↓ | 195 |
| CtIP | Tumor suppressor | ↓ | 107 |
| DAXX | Tumor suppressor | ↓ | 196 |
| FADD | Tumor suppressor | ↓ | 197 |
| FBXW7 | Tumor suppressor | ↓ | 198 |
| FOXO4 | Tumor suppressor | ↓ | 199 |
| IRF3 | Tumor suppressor | ↓ | 200 |
| KLF10 | Tumor suppressor | ↓ | 201 |
| PML | Tumor suppressor | ↓ | 202 |
| pRb | Tumor suppressor | ↓ | 203 |
| RARα | Tumor suppressor | ↓ | 186 |
| RUNX3 | Tumor suppressor | ↓ | 204 |
| SMRT | Tumor suppressor | ↓ | 205 |
| AMPK | Growth-inhibitory regulator | ↓ | 206 |
| ATR | Growth-inhibitory regulator | ↓ | 207 |
| AUF1 | Growth-inhibitory regulator | ↓ | 208 |
| BTK | Growth-inhibitory regulator | ↓ | 209 |
| Che1 | Growth-inhibitory regulator | ↓ | 210 |
| GRK2 | Growth-inhibitory regulator | ↓ | 211 |
| p27 | Growth-inhibitory regulator | ↓ | 212 |
| PIP4K | Growth-inhibitory regulator | ↓ | 213 |
| RBBP8 | Growth-inhibitory regulator | ↓ | 107 |
| SMAD | Growth-inhibitory regulator | ↓ | 55 |
| Smad3 | Growth-inhibitory regulator | ↓ | 214 |
| SUV39H1 | Growth-inhibitory regulator | ↓ | 215 |
| TRF1 | Growth-inhibitory regulator | ↓ | 216 |
| XPO5 | Growth-inhibitory regulator | ↓ | 217 |
AIB1: amplified in breast cancer 1; AKT: the serine/threonine protein kinase B; AMPK: AMP-activated protein kinase; AR: androgen receptor; ATR: ataxia telangiectasia and Rad3 related; BCL2: B-cell lymphoma 2; CDC25: cell division
cycle 25; CDK10: cyclin-dependent kinase 10; Cep55: centrosome protein 55; COX2: cyclooxygenase-2; ER: estrogen receptor; FAK: focal adhesion kinase; FBXW7 : F-box and WD40 repeat domain containing-7; FOXM1: forkhead box M1; FOXO4: forkhead box O4; HBX: hepatitis B virus X-protein; HER2: human epidermal growth factor receptor 2; HIF-1: hypoxia-inducible transcription factor-1; HSF1: heat shock transcription factor 1; IRAK1: interleukin-1 receptor-associated kinase 1; IRF3: interferon-regulatory factor 3; KLF10: kruppel-like factor 10; MCL1: myeloid cell leukemia-1; NF-κB: nuclear factor kappa-light-chain- enhancer of activated B cells; OCT4: octamer 4; PGK1: phosphoglycerate kinase 1; PKM2: pyruvate kinase M2; PLK: polo-like kinase; PML: promyelocytic leukemia protein; PML-RARα: promyelocytic leukemia- retinoic acid receptor alpha; pRb: retinoblastoma protein; PTP: protein tyrosine phosphatase; RARα: retinoic acid receptor alpha; RSK2: ribosomal protein S6 kinase 2; RUNX3: runt-related transcription factors 3; S6K: S6 kinase; SMRT: silencing mediator for retinoic acid and thyroid hormone receptor; STAT3: signal transducer and activator of transcription 3; XBP1: X-box-binding protein 1.