Figure 8.

Schematic illustrating the role of PHB2 in regulating NSCLC tumorigenesis. PHB2 is a pivotal tumorigenic factor involved in the cellular processes of proliferation, apoptosis, migration, and invasion of NSCLC cells. PHB2 interacts with RACK1 and increases RACK1 protein expression, which further upregulates the amount of integrin β1 pulled down by RACK1 and induces activation of the Akt and FAK pathways in NSCLC cells. The crosstalk between PHB2 and RACK1 may play an important role in regulating tumorigenesis in NSCLC.