Table 1.
Preliminary Screening of Mixed Polymeric Micellar Formulations with Various Ratios of Different Amphiphiles (NaDOC, PP123, PF68, PF87, PF127, PF108, and PL121, CRH40 and CELP) and Lecithin
| Amphiphile (HLB) | H/M:Lecithin:Amphiphile | |||||
|---|---|---|---|---|---|---|
| 1:0:5 | 1:1:5 | 1:0:10 | 1:1:10 | 1:0:20 | 1:1:20 | |
| NaDOC (16) |
1300.6 ± 316.48a,c (1.177 ± 0.832)b |
227.8 ± 45.86 (0.631 ± 0.238) | 169.6 ± 152.14 (5.877 ± 11.17) | 215.7 ± 131.03 (1.211 ± 0.289) | 234.7 ± 152.33 (0.456 ± 1.385) | 636.3 ± 286.29 (0.035 ± 0.97) |
| PF68 (>24) | 346.2 ± 8.48 (0.091 ± 0.124) | 986.9 ± 484.23 (1.461 ± 0.068) | 105.6 ± 5.91 (0.129 ± 0.041) | 641.5 ± 5.39 (0.495 ± 0.149) | 103.9 ± 6.35 (1.26 ± 0.335) | 448.2 ± 26.41 (0.655 ± 0.066) |
| PF108 (>24) | 29.9 ± 3.11 (0.675 ± 0.159) | 746.7 ± 50.79 (0.603 ± 0.139) | 35.1 ± 3.16 (0.762 ± 0.364) | 392.7 ± 11.01 (0.546 ± 0.067) | 30.2 ± 5.16 (0.725 ± 0.364) | 253.9 ± 3.14 (0.466 ± 0.1) |
| PF87 (>24) | 21.8 ± 6.42 (0.275 ± 1.492) | 701.1 ± 134.1 (0.816 ± 0.258) | 191.3 ± 126.22 (23.08 ± 33.43) | 882.2 ± 14.06 (0.211 ± 0.099) | 28.4 ± 6.31 (2.124 ± 0.488) | 1054 ± 267.64 (0.033 ± 1.068) |
| PF127 (18–23) | 30.9 ± 2.73 (0.558 ± 0.364) | 2243 ± 1819 (1.313 ± 0.258) | 29.2 ± 1.6 (1.26 ± 0.35) | 772.5 ± 101.9 (1.51 ± 0.07) | 47.7 ± 47.9 (1.379 ± 1.508) | 854.6 ± 336.8 (1.621±0.068) |
| PL121 (1–7) | ≥3000 | ≥3000 | ≥3000 | ≥3000 | ≥3000 | ≥3000 |
| PP123 (7–9) | 1181.6 ± 51.21 (1.305 ± 0.028) | 371.7 ± 12.77 (1.033 ± 0.016) | 120.3 ± 9.87 (0.343 ± 0.297) | 149.2 ± 1.49 (0.686 ± 0.037) | 122.9 ± 5.89 (0.552 ± 0.091) | 100 ± 7.12 (0.899 ± 0.062) |
| CRH40 (14.3) | 198.6 ± 0.88 (0.466 ± 0.022) | 256.3 ± 7.54 (0.87 ± 0.039) | 115 ± 1.42 (1.203 ± 0.063) | 348.6 ± 2.75 (1.044 ± 0.064) | 28.2 ± 14.29 (0.976 ± 3.515) | 322.4 ± 17.37 (1.969 ± 0.026) |
| CELP (13.9) | 164.6 ± 1.57 (0.755 ± 0.01) |
235 ± 3.24 (0.758 ± 0.029) |
20.3±1.03 (0.862 ± 0.634) | 302.5 ± 8.194 (1.298 ± 0.042) | 16.2 ± 6.45 (1.044 ± 0.273) | 98.6 ± 11.15 (1.591 ± 0.101) |
Notes: aMean size±standard deviation (SD). bMean polydispersity index±SD. cUnderlining indicates precipitation during 12 h.
Abbreviations: H/M, honokiol-magnolol; HLB, hydrophilic-lipophilic balance.