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. 2021 Jan 25;15:277–287. doi: 10.2147/DDDT.S267856

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© 2021 Dong et al.

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Physcion attenuates OGD/R-induced injury in SH-SY5Y cells via inhibiting the TLR4/p65 pathway. SH-SY5Y cells were exposed to OGD for 4 h, and then reoxygenated in the presence of 40 μM Oroxylin A for 24 h. (A) Expression levels of TLR4, p-p65, p-IκB in SH-SY5Y cells were detected with Western blotting. (B–D) The relative expressions of TLR4, p-p65, p-IκB in cells were quantified via normalization to β-actin, p65 and IκB. **P<0.01 compared with control group; ^##P<0.01 compared with OGD/R group.

Abbreviations: OGD/R, oxygen-glucose deprivation/reperfusion; p-IκB, phospho-IκB; p65, NF-κB p65; p-p65, phospho-NF-κB p65; TLR4, toll-like receptor 4.