Table 1. Studies showing the mechanisms of action of CGRP mAbs and botox.

CGRP: calcitonin gene-related peptide; mAbs: monoclonal antibodies; botox: OnabotulinumtoxinA.

Author and year of pub	Drug studied	Type of study	Results	Conclusion
Russo et al. 2015 [15]	CGRP mAbs	Review	CGRP is a vital neurotransmitter that plays a role in migraines.	Antagonists and mAbs against CGRP can be helpful in preventing migraines.
Moriarty et al., 2019 [16]	CGRP mAbs	Review	CGRP plays a main role in the vasodilation and sensation of trigeminovascular system.	CGRP mAbs are useful in preventing migraines and have many advantages.
Cavestro et al., 2019 [17]	CGRP mAbs	Review	Specific neurotransmitters such as CGRP are thought to play a role in migraines through the trigeminovascular system.	Monoclonal antibodies against CGRP can be used as a treatment for migraines.
Yuan et al., 2020 [18]	Botox	Review	Botox disrupts neuropeptide secretion that is related to trigeminal signaling, preventing the sensation of pain.	Botox is safe and efficacious in preventing chronic migraines.
Lew et al., 2002 [14]	Botox	Review	Botox inhibits acetylcholine release, leading to local paralysis and blockade of pain.	Botox can help with pain relief via its mechanism of action.
Escher et al., 2017 [19]	Botox	Review	Botox is a migraine prophylactic that might work by inhibiting acetylcholine release and CGRP release.	Botox can inhibit migraine pain via blocking acetylcholine release.
Szok et al., 2015 [20]	Botox	Review	155-195 units of botox were found to be effective in patients.	Botox was effective in preventing migraines in patients.