Table 2.
Microvascular assessments pre- and post-bariatric surgery
| Parameter | Baseline (n = 26) | 12 months (n = 26) | p |
|---|---|---|---|
| Neuropathy assessment | |||
| NSP (x/38) | 3 (0–5) | 0 (0–1) | < 0.001 |
| NDS (x/10) | 1 (0–3) | 0 (0–2) | 0.068 |
| VPT (volts) | 14.2 (7.06) | 13.6 (7.11) | 0.969 |
| CPT (°C) | 25.7 (20.0–28.1) | 26.3 (22.0–28.3) | 0.702 |
| WPT (°C) | 40.0 (3.98) | 41.3 (4.76) | 0.093 |
| DB-HRV (beats/min) | 15 (12–22) | 14 (11–20) | 0.670 |
| CNFD (no./mm2) | 27.1 (20.8–30.2) | 29.2 (25–34.9) | 0.005 |
| CNBD (no./mm2) | 63.4 (35.1) | 77.8 (35.5) | 0.008 |
| CNFL (mm/mm2) | 20.0 (15.8–22.7) | 20.2 (18.3–23.8) | 0.001 |
| Renal assessment | |||
| uACR (mg/mmol) | 1.00 (0.57–1.71) | 0.50 (0.34–1.00) | 0.103 |
| sCreat (μmol/l) (mg/dl) |
77 (27) 0.87 (0.31) |
66 (17) 0.75 (0.19) |
< 0.001 |
| sCysC (mg/l) | 0.9 (0.72–1.03) | 0.87 (0.79–1.11) | 0.348 |
| eGFR (ml/min) | 128 (26) | 120 (23) | 0.015 |
Data are presented as mean (SD) or median (interquartile range). Variables in bold are statistically significant (p < 0.05)
There was a significant improvement in the NSP, CNFD, CNBD and CNFL (p < 0.01). Other variables showed a non-significant trend towards improvement
NSP neuropathy symptom profile, NDS, neuropathy disability score, VPT vibration perception threshold, CPT cold perception threshold, WT warm perception threshold, DB-HRV deep breathing heart rate variability, CNFD corneal nerve fibre density, CNBD corneal nerve branch density, CNFL corneal nerve fibre length, ACR albumin/creatinine ratio, sCreat serum creatinine, sCysC serum cystatin C, eGFR estimated glomerular filtration rate