Table 2.
Left ventricular ejection fraction by visit (FAS population)
| Anagrelide n = 73 |
Hydroxyurea n = 68 |
|||
|---|---|---|---|---|
| LVEF at visit (%) | Change from baselinea (%) | LVEF at visit (%) | Change from baseline a (%) | |
| Baseline | ||||
| n | 73 | 68 | ||
| Mean (SD) | 66.4 (4.81) | 66.9 (4.59) | ||
| Median (min, max) | 66.0 (55, 88) | 67.0 (55, 78) | ||
| Month 1 | ||||
| n | 71 | 71 | 64 | 64 |
| Mean (SD) | 66.8 (3.79) | 0.5 (4.68) | 65.6 (4.07) | − 1.1 (4.73) |
| Median (min, max) | 67.0 (58, 77) | 1.0 (− 13, 10) | 66.0 (59, 79) | − 1.0 (− 16, 12) |
| Month 2 | ||||
| n | 68 | 68 | 63 | 63 |
| Mean (SD) | 67.5 (4.00) | 1.2 (5.80) | 66.7 (4.66) | 0 (5.03) |
| Median (min, max) | 67.0 (56, 80) | 1.0 (− 23, 19) | 67.0 (58, 81) | 0 (− 13, 16) |
| Month 3 | ||||
| n | 67 | 67 | 62 | 62 |
| Mean (SD) | 66.4 (4.90) | 0.1 (5.31) | 66.3 (4.19) | − 0.4 (3.94) |
| Median (min, max) | 66.0 (57, 87) | − 1.0 (− 13, 24) | 66.0 (50, 73) | − 1.0 (− 11, 11) |
| Month 6 | ||||
| n | 59 | 59 | 60 | 60 |
| Mean (SD) | 65.9 (5.13) | − 0.5 (5.68) | 66.1 (3.97) | − 0.6 (3.95) |
| Median (min, max) | 66.0 (48, 80) | 0 (− 23, 11) | 66.0 (56, 77) | − 0.5 (− 9, 11) |
| Month 9 | ||||
| n | 52 | 52 | 52 | 52 |
| Mean (SD) | 65.9 (5.12) | − 0.8 (4.78) | 64.8 (3.97) | − 1.5 (5.15) |
| Median (min, max) | 66.0 (51, 77) | 0 (− 14, 9) | 65.0 (56, 75) | − 2.0 (21, 10) |
| Month 12 | ||||
| n | 45 | 45 | 52 | 52 |
| Mean (SD) | 65.9 (3.73) | − 0.8 (6.61) | 65.7 (4.12) | − 0.6 (5.67) |
| Median (min, max) | 66.0 (56, 72) | − 1.0 (− 18, 15) | 65.0 (58, 78) | 0.0 (− 13, 13) |
| Month 18 | ||||
| n | 41 | 41 | 48 | 48 |
| Mean (SD) | 64.4 (3.92) | − 2.0 (5.54) | 64.7 (4.47) | − 1.2 (4.84) |
| Median (min, max) | 65.0 (54, 73) | − 2.0 (− 15, 8) | 65.0 (54, 74) | − 1.0 (− 23, 7) |
| Month 24 | ||||
| n | 40 | 40 | 49 | 49 |
| Mean (SD) | 64.7 (3.88) | − 1.8 (5.84) | 64.2 (3.72) | − 0.2 (6.17) |
| Median (min, max) | 65.0 (57, 73) | − 1.0 (− 18, 16) | 65.0 (54, 72) | 0 (− 23, 12) |
| Month 30 | ||||
| n | 40 | 40 | 45 | 45 |
| Mean (SD) | 64.7 (3.41) | − 1.8 (5.84) | 65.5 (4.08) | − 0.2 (5.38) |
| Median (min, max) | 65.0 (58, 71) | − 1.5 (− 23, 10) | 65.0 (55, 74) | 0 (− 19, 15) |
| Month 36 | ||||
| n | 40 | 40 | 44 | 44 |
| Mean (SD) | 64.8 (3.17) | − 1.7 (6.55) | 65.1 (3.73) | − 0.6 (5.46) |
| Median (min, max) | 65.5 (58, 71) | − 1.0 (− 25, 15) | 65.0 (57, 75) | − 1.0 (− 14, 11) |
LVEF, left ventricular ejection fraction; SD, standard deviation
aBaseline corresponds to the first valid (non-missing interpretation) observation obtained at the baseline visit; if this was missing, the screening value was used