Table 4.
Platelet count at Months 3, 6 and 36 (FAS population)
| Study visit | Anagrelide n = 73 |
Hydroxyurea n = 68 |
||
|---|---|---|---|---|
| Observed value (× 109/L) | Change from baselinea | Observed value (× 109/L) | Change from baselinea | |
| Screening | ||||
| nb | 73 | NA | 68 | NA |
| Mean (SD) | 1056.5 (330.03) | NA | 1177.6 (459.50) | NA |
| Median (min, max) | 1016.0 (552, 2882) | NA | 1094.0 (621, 3772) | NA |
| Baseline | ||||
| nb | 73 | NA | 68 | NA |
| Mean (SD) | 1076.0 (294.42) | NA | 1159.1 (435.30) | NA |
| Median (min, max) | 1027.0 (601, 2077) | NA | 1116.5 (583, 3432) | NA |
| Month 3 | ||||
| nb | 67 | 67 | 62 | 62 |
| Mean (SD) | 487.5 (211.44) | − 597.3 (331.70) | 396.4 (170.33) | − 745.6 (345.46) |
| Median (min, max) | 435.0 (160, 1314) | − 626.0 (− 1642, 121) | 372.5 (82, 1219) | − 655.0 (− 2326, − 214) |
| Month 6 | ||||
| nb | 60 | 60 | 58 | 58 |
| Mean (SD) | 418.6 (135.96) | − 660.4 (278.22) | 396.0 (144.07) | − 751.6 (294.26) |
| Median (min, max) | 398.5 (181, 779) | − 657.5 (− 1301, 134) | 389.5 (102, 833) | − 729.0 (− 2037, − 264) |
| Month 36 | ||||
| nb | 40 | 40 | 43 | 43 |
| Mean (SD) | 384.9 (126.29) | − 742.2 (262.14) | 446.6 (144.35) | − 727.6 (349.81) |
| Median (min, max) | 386.0 (193, 748) | − 741.5 (− 1297, − 223) | 435.0 (170, 886) | − 596.0 (− 1924, − 201) |
NA not applicable; SD standard deviation
aBaseline corresponds to the first valid (non-missing interpretation) observation obtained at the baseline visit; if this was missing, the screening value was used
bIf a value was missing at a visit, the subject was not included in the n for that visit