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. 2021 Jan 18;14:617973. doi: 10.3389/fnins.2020.617973

FIGURE 2.

FIGURE 2

Rats undergoing long-term withdrawal from oxycodone showed increased expression of AMPA receptor mRNA. (A–C) GluA1 mRNA expression is significantly increased in the LgA-H group compared to SAL at 31 days and showed a significant correlation with lever pressing on WD30. (D–F) GluA2 mRNA expression is significantly increased in the LgA-L and LgA-H groups compared to the SAL and ShA groups at 31 days and showed a significant correlation with lever pressing on WD30. (G–I) GluA3 mRNA expression is significantly increased in the LgA-L compared to the SAL and ShA grops as well as in the LgA-H group compared to the ShA group at 31 days and showed a significant correlation with lever pressing on WD30. (J–L) GluA4 mRNA expression is significantly decreased (in the LgA-L and LgA-H group compared to SAL at 2 h and showed no significant correlation between 31 day mRNA expression and lever pressing on WD30. Key to statistics: *, **, = p < 0.05, 0.01, respectively, in comparison to Sal rats; #, ##, ### = p < 0.05, 0.01, 0.001, respectively, in comparison to ShA rats. Statistical Analyses were performed by One Way ANOVA followed by Fisher’s PLSD post hoc test, and correlation was tested by simple linear regression.)