Figure 7.

Dynamic Spearman correlations of IL-17A vs. GM-CSF, IL-10, or IL-22 suggest distinct trajectories of IL-17A–producing T cell subsets in trauma patient sub-groups. Spearman Correlations were carried out over 1-day time intervals using the data on IL-17A, IL-22, GM-CSF, and IL-10 in Groups 1–3. Significant correlations between IL-17A and GM-CSF were inferred to suggest the presence of pathogenic Th17 cells, significant correlations between IL-17A and IL-10 were inferred to suggest the presence of non-pathogenic Th17 cells, and significant correlations between IL-17A and IL-22 were inferred to suggest the presence of γδ 17 T cells. (A) In Group 1, non-pathogenic Th17 cells reached significant (p < 0.05) r values between days 3 and 5 post-admission and were inferred to predominate over pathogenic Th17 cells from day 2 to 7. (B) In Group 2, both pathogenic and non-pathogenic Th17 cell subsets showed similar r values, with a steady rise during the time course of 7 days after admission. (C) In Group 3, pathogenic Th17 cells appeared to predominate over non-pathogenic Th17 cells up to day 2. Thereafter, pathogenic and non-pathogenic Th17 cell subsets appeared to follow similar dynamics through day 7. Significant correlations between IL-17A and IL-22 were observed only in Group 1 (days 3–4) and Group 3 (all days). For exact r- and p-values, see Table S1 .