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. 2021 Jan 18;10:577118. doi: 10.3389/fonc.2020.577118

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Copyright © 2021 Wang, Li, Lu and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biogenesis of circRNA. (A) Pre-mRNA can be transcribed into linear mRNA via canonical splicing or produce circRNAs including EcRNA, EIcRNA, and CiRNA through back-splicing. EcRNAs and CiRNAs only contain exons and introns respectively, while EIcRNAs consist of both. circRNAs can also be originated from lncRNAs via back-splicing, such as CDR1as and circLINC-PINT. (B) The intron excision of pre-tRNA occurs when the tRNA splicing endonuclease complex (TSEN) binds to the bulge-helix-bulge (BHB) motif to release tRNA and tricRNA.