Table 1.
circRNAs act as miRNA sponges in human cancer.
| Cancer | circRNA | Change | Target miRNA | Effect | Ref |
|---|---|---|---|---|---|
| Bladder cancer | circCEP128 | Up | miR-145 | oncogenic | (15, 16) |
| circFNTA | Up | miR-370-3p, miR-451a | oncogenic | (17, 18) | |
| circHIPK3 | Down | miR-558 | suppressive | (19) | |
| circITCH | Down | miR-17, miR-224 | suppressive | (20) | |
| circMTO1 | Down | miR-221 | suppressive | (21) | |
| circPTPRA | Down | miR-636 | suppressive | (22) | |
| circVANGL1 | Up | miR-605-3p, miR-1184 | oncogenic | (23, 24) | |
| circZFR | Up | miR-377 | oncogenic | (25) | |
| circZKSCAN1 | Down | miR-1178-3p | suppressive | (26) | |
| CDR1as | Down | miR-135a | suppressive | (27) | |
| circFNDC3B | Down | miR-1178-3p | suppressive | (28) | |
| BC | CDR1as | Up | miR-1299 | oncogenic | (29) |
| circABCB10 | Up | miR-1271 | oncogenic | (30) | |
| circAGFG1 | Up | miR-195 | oncogenic | (31) | |
| circANKS1B | Up | miR-148a, miR-152-3p | oncogenic | (32) | |
| circCDYL | Up | miR-1275 | oncogenic | (33) | |
| circDENND4C | Up | miR-200b, miR-200c | oncogenic | (34) | |
| circEPSTI1 | Up | miR-4753, miR-6809 | oncogenic | (35) | |
| circGFRA1 | Up | miR-34a | oncogenic | (36) | |
| circITCH | Down | miR-214, miR-17 | suppressive | (37) | |
| circUBAP2 | Up | miR-661 | oncogenic | (38) | |
| circZNF609 | Up | miR-145 | oncogenic | (39) | |
| CRC | CDR1as | Up | miR-7 | oncogenic | (40) |
| circANKS1B | Up | miR-149 | oncogenic | (41) | |
| circCDYL | Down | miR-150 | suppressive | (42) | |
| circCSPP1 | Up | miR-361 | oncogenic | (43) | |
| circDENND4C | Up | miR-760 | oncogenic | (44) | |
| circHIPK3 | Up | miR-7, miR-1207-5p | oncogenic | (45, 46) | |
| circITGA7 | Down | miR-370-3p, miR-3187-3p | suppressive | (47, 48) | |
| circMTO1 | Down | miR-19b | suppressive | (49) | |
| circPIP5K1A | Up | miR-1273a | oncogenic | (50) | |
| circPRMT5 | Up | miR-377 | oncogenic | (51) | |
| circPVT1 | Up | miR-145 | oncogenic | (52) | |
| circVAPA | Up | miR-101, miR-125a | oncogenic | (53, 54) | |
| circZNF609 | Up | miR-150 | oncogenic | (55) | |
| GC | CDR1as | Up | miR-7 | oncogenic | (56) |
| circHIAT1 | Down | miR-21 | suppressive | (57) | |
| circHIPK3 | Up | miR-107 | oncogenic | (58) | |
| circLARP4 | Down | miR-424 | suppressive | (59) | |
| circMAN2B2 | Up | miR-145 | oncogenic | (60) | |
| circMTO1 | Down | miR-3200-5p | suppressive | (61) | |
| circPIP5K1A | Up | miR-376c, miR-671 | oncogenic | (62, 63) | |
| circPRKCI | Up | miR-545 | oncogenic | (64) | |
| circPRMT5 | Up | miR-145 | oncogenic | (65) | |
| circPVT1 | Up | miR-125 | oncogenic | (66) | |
| circZFR | Down | miR-130a, miR-107 | suppressive | (67) | |
| circZNF609 | Up | miR-145 | oncogenic | (68) | |
| HCC | CDR1as | Up | miR-7, miR-1270 | oncogenic | (69, 70) |
| circABCB10 | Up | miR-670-3p | oncogenic | (71) | |
| circBIRC6 | Up | miR-3918 | oncogenic | (72) | |
| circCDYL | Up | miR-892a, miR-328-3p | oncogenic | (73) | |
| circHIAT1 | Down | miR-3171 | suppressive | (74) | |
| circHIPK3 | Up | miR-124 | oncogenic | (75) | |
| circLARP4 | Down | miR-761 | suppressive | (76) | |
| circMAN2B2 | Up | miR-217 | oncogenic | (77) | |
| circMTO1 | Down | miR-9 | suppressive | (78) | |
| circMYLK | Up | miR-362-3p | oncogenic | (79) | |
| circPRKCI | Up | miR-545 | oncogenic | (80) | |
| circPRMT5 | Up | miR-188 | oncogenic | (81) | |
| circPVT1 | Up | miR-203, miR-3666 | oncogenic | (82, 83) | |
| circVAPA | Up | miR-377 | oncogenic | (84) | |
| circZFR | Up | miR-511 | oncogenic | (85) | |
| circZNF652 | Up | miR-203, miR-502 | oncogenic | (86) | |
| NSCLC | CDR1as | Up | miR-7, miR-219 | oncogenic | (87–89) |
| circAGFG1 | Up | miR-203 | oncogenic | (90) | |
| circBIRC6 | Up | miR-145 | oncogenic | (91) | |
| circFOXM1 | Up | miR-614, miR-1304-5p | oncogenic | (92, 93) | |
| circGFRA1 | Up | miR-183-3p | oncogenic | (94) | |
| circHIPK3 | Up | miR-149 | oncogenic | (95) | |
| circNT5E | Up | miR-134 | oncogenic | (96) | |
| circPIP5K1A | Up | miR-136, miR-142-5p | oncogenic | (97, 98) | |
| circPRMT5 | Up | miR-377, miR-382, miR-498 | oncogenic | (99) | |
| circPTPRA | Down | miR-96 | suppressive | (100) | |
| circPVT1 | Up | miR-125b, miR-497 | oncogenic | (101, 102) | |
| circSMARCA5 | Down | miR-19b | suppressive | (103) | |
| circVANGL1 | Up | miR-195 | oncogenic | (104) | |
| circZFR | Up | miR-101 | oncogenic | (105) | |
| circZKSCAN1 | Up | miR-330-5p | oncogenic | (106) |
CRC, colorectal cancer; HCC, hepatocellular carcinoma; NSCLC, non-small-cell lung cancer.