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. 2021 Jan 18;11:540591. doi: 10.3389/fphys.2020.540591

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Copyright © 2021 Liu, Liu, Li, Zhang, Chen, Zhang, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACE2 was involved in mechanical stretch-induced vascular smooth muscle cells (VSMC) dysfunction. VSMCs were transfected with Ad-ACE2 or Ad-GFP for 24 h and then exposed to mechanical stretch (18% elongation, 1 Hz) for 12 h or not. (A,B) Representative views of BrdU-positive cells in different conditions and the percentage of BrdU-positive cells out of total cells. (C,D) Representative views of migration distance in different conditions. (E,F) Summarized data showing cell apoptosis as determined by flow cytometry analysis in VSMCs. (G,H) Western blot analysis of collagen I and collagen III in VSMCs with or without overexpression of ACE2. Values are expressed as means ± SEM. ^∗P < 0.05 vs. Ad-GFP; ^#P < 0.05 vs. 18% stretch + Ad-GFP (n = 4).