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. 2021 Jan 18;11:624677. doi: 10.3389/fphys.2020.624677

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Copyright © 2021 Fu, Gillen, Grabek, Riemondy, Epperson, Bustamante, Hesselberth and Martin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially-expressed genes across circannual rhythm of hibernation in three brain regions. (A–C) Circles represent the homeothermic (red) and heterothermic (blue) portions of the hibernator’s year, arrows the sequence of physiological transitions. Two numbers are given on the inside of each arrow, decreasing in gray, increasing in black; their sum is the total DE between those two states (Supplementary Figure 2). Numbers outside the circles are the total number of DE genes (q < 0.001)/number of pass-filter genes detected in that brain region. (D) Venn diagram of common and unique DE genes among the three brain regions.