Table 1.

The role of ncRNA-mediated SIRT1 changes in diabetic retinopathy.

ncRNAs	Model	Effect on expression of SIRT1	Functions regulated	References
miR-211	STZ-induced diabetic Wistar rats and HUVEC	Inhibition	Apoptosis	Liu et al. (88)
miR-29b-3p	HRMEC	Inhibition	Apoptosis	Zeng et al. (89)
miR-221	HRMEC	Inhibition	Apoptosis	Chen et al. (90)
miR-34a	ARPE-19	Inhibition	Inflammation and apoptosis	Tong et al. (91)
miR-217	ARPE-19	Inhibition	Inflammation and apoptosis	Xiao et al. (92)
miR-195	STZ-induced diabetic Sprague-Dawley rats, HRMEC and HMEC	Inhibition	Oxidative stress and production of ECM proteins	Mortuza et al. (93)
miR-377	HREC	Inhibition	Angiogenesis and inflammation	Cui et al. (94)
miR-543	HREC	Inhibition	Angiogenesis	Ke et al. (95)
miR-204	PRPEC and ARPE-19	Inhibition	ER stress and apoptosis	Peng et al. (96)
miR-204	High-fat diet and STZ-induced mice and MIO-M1	Inhibition	Inflammation	Tu et al. (97)
LncRNA MEG3	ARPE-19	Activation	Inflammation and apoptosis	Tong et al. (91)
LncRNA MEG3	High-fat diet and STZ-induced mice and MIO-M1	Activation	Inflammation	Tu et al. (97)
LncRNA SNHG7	HREC	Activation	Angiogenesis	Ke et al. (95)

SIRT1, Sirtuin 1; ncRNA, non-coding RNA; miR, microRNA; LncRNA MEG3, long non-coding RNA maternally expressed gene 3; SNHG7, small nucleolar RNA host gene 7; ECM, extracellular matrix; ER, endoplasmic reticulum; STZ, streptozocin; EC, epithelial cell; HUVEC, human umbilical vein EC; HRMEC, human retinal microvascular EC; ARPE-19, human retinal pigment EC; HREC, human retinal EC; HMEC, human dermal microvascular EC; PRPEC, primary retinal pigment EC; MIO-M1, human Müller cell line.