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. 2021 Jan 18;11:603235. doi: 10.3389/fphar.2020.603235

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Copyright © 2021 Sandhiutami, Arozal, Louisa, Rahmat and Wuyung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macroscopic appearance, volume and weight of the rat ovaries after treatment with cisplatin, cisplatin + curcumin or cisplatin + nanocurcumin (A (1–5)) macroscopic appearance of the rat ovaries (A-1) normal/sham (A-2) ovarian cancer (A-3) ovarian cancer rats treated with cisplatin (A-4) ovarian cancer rats treated with cisplatin + curcumin (A-5) ovarian cancer rats treated with cisplatin and nanocurcumin (B) ovarian volume (cm³) and (C) ovarian weight (G). Data are presented in mean ± SD and obtained from five rats per group. (A) p value < 0.05 vs. N (sham); (B) p value <0.05 vs. N: Normal/Sham; OC: Ovarian Cancer; OC + Cis: Ovarian Cancer + Cisplatin; OC + Cis + Cur: Ovarian Cancer + Cisplatin + Curcumin; OC + Cis + NC: Ovarian Cancer + Cisplatin + Nanocurcumin.