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. 2021 Jan 18;11:603235. doi: 10.3389/fphar.2020.603235

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Copyright © 2021 Sandhiutami, Arozal, Louisa, Rahmat and Wuyung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased TGF-β/PI3K/Akt in rat ovaries after treatment with cisplatin or cisplatin + curcumin or cisplatin + nanocurcumin (A) Decreased levels of active TGF-β (pg/mg protein) (B) Western blot analysis for PI3K (normalized to β-actin as control), and phospho (p)-Akt (normalized to Akt as control) (C) Downregulation of PI3K/β-actin expressions (D) Decreased p-Akt/Akt (arb unit). Full blot data are available in Supplementary Material. (A) p value < 0.05 vs. N (sham) group; (B) p value < 0.05 vs. OC; (C) p value < 0.05 vs. OC + Cis; (D) p value < 0.05 vs. OC + Cis + Cur.