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. 2021 Jan 18;14:614884. doi: 10.3389/fnbeh.2020.614884

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Copyright © 2021 Eren-Yazicioglu, Yigit, Dogruoz and Yapici-Eser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic drawing of reversed reward responses after GLP-1 modulation. In addition to the systematic injection of GLP-1 agonists' effects on the brain; LH, VTA, NAc, NTS, SUM, and LS were studied for palatable food, whereas VTA, NAc, and NTE were studied for alcohol, NAc was studied for amphetamine, NAc and LS were for cocaine and NTS was for nicotine use behavior. Areas were drawn based on Allen Mouse Brain Atlas (NAc, nucleus accumbens; LS, lateral septum; HPF, hippocampal formation; LH, lateral hypothalamus; VTA, ventral tegmental area; SUM, supramammillary nucleus; NTS, nucleus tractus solitarius; BNST, bed nucleus of the stria terminalis).