Table 1.
Inhibition on Ishikawa Cells of Cordycepin, Cisplatin, and Their Combinations
| Compounds (Concentration) | Inhibition Rate | p Values |
|---|---|---|
| Cordycepin (12.5 μg/ml) | 4.7% ± 1.8% | 0.02 |
| Cordycepin (25 μg/ml) | 9.7% ± 1.8% | <0.01 |
| Cordycepin (50 μg/ml) | 32.9% ± 1.2% | <0.01 |
| Cordycepin (100 μg/ml) | 57.1% ± 3.4% | <0.01 |
| Cisplatin (0.5 μg/ml) | 5.9% ± 2.4% | 0.04 |
| Cisplatin (1 μg/ml) | 19.6% ± 2.4% | <0.01 |
| Cisplatin (2 μg/ml) | 29.6% ± 1.8% | <0.01 |
| Cisplatin (4 μg/ml) | 51.6% ± 1.4% | <0.01 |
| Cordycepin (12.5 μg/ml) plus cisplatin (0.5 μg/ml) | 21.3% ± 2.1% | 0.04 |
| Cordycepin (12.5 μg/ml) plus cisplatin (1 μg/ml) | 26.6% ± 3.0% | 0.02 |
| Cordycepin (12.5 μg/ml) plus cisplatin (2 μg/ml) | 34.8% ± 0.8% | 0.02 |
| Cordycepin (12.5 μg/ml) plus cisplatin (4 μg/ml) | 76.8% ± 0.4% | <0.01 |
| Cordycepin (25 μg/ml) plus cisplatin (0.5 μg/ml) | 24.3% ± 2.6% | <0.01 |
| Cordycepin (25 μg/ml) plus cisplatin (1 μg/ml) | 33.7% ± 2.1% | <0.01 |
| Cordycepin (25 μg/ml) plus cisplatin (2 μg/ml) | 40.6% ± 1.5% | <0.01 |
| Cordycepin (25 μg/ml) plus cisplatin (4 μg/ml) | 80.1% ± 0.3% | <0.01 |