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. 2019 Jul 12;27(7):779–788. doi: 10.3727/096504018X15442985680348

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Copyright © 2019 Cognizant, LLC.

This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.

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PAR2 inhibition produces similar effects as PAR2 depletion. (A) HCT116 cells were treated with 50 μg/ml of 5-FU together with/without 10 μmol/L ENMD-547 pretreatment for 1 day, after which the expression of the indicated proteins was examined through immunoblotting. (B) HCT116 cells were processed as in (A), and the expression of the indicated genes was analyzed using RT-PCR. (C) HCT116 cells were treated as in (A), and then cell survival was examined using the MTS assay. (D) HCT116 cells were processed as in (A), after which caspase 3/7 activity was analyzed. (E) HCT116 cells were processed as in (A), and then the migration of the surviving cells after treatment was analyzed.